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KMID : 1094020120290030203
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Journal of Veterinary Clinics
2012 Volume.29 No. 3 p.203 ~ p.206
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홈 > 한국임상수의학회지 > 한국임상수의학회지 제29권 제3호
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Han Suk-Hee
Kim Ye-Won
Hyun Chang-Baig
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Abstract
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Treatment for heart failure is directed to reduce atrial volume overload by diuretic agents, to lessen ventricular pressure overload by vasodilatory agents and to increase myocardial performance through inotropic agents. Of those cardiac therapeutics, diuretic agents are the most important to control heart failure in dogs, although long-term use often causes detrimental side-effects such as acute renal failure and electrolyte abnormalities. Thus, this study was designed to find a new diuretic agent from medicinal herbs which has better diuretic effect and less unfavorable complications in dogs. In a preliminary study performed with 5 normal healthy dogs, the extract from Akebia quinata Decaisne showed mild to moderate diuretic effect (0.3-0.5 potency of furosemide 2 mg/kg) and minimal changes in serum chemistry and electrolyte. Although the study population was not large enough and study period was not sufficient enough, this study found a good alternative diuretic agent which can replace or reduce the use of furosemide in dogs with heart failure.
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KEYWORD
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diuretics, Akebia quinata Decaisne, heart failure, CMVI, dogs
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